This chapter discusses the roles of transnational multiple stakeholder partnerships in addressing development and implementation challenges affecting youth and children in both rich as well as low- and middle-income countries. We first discuss each of five major sets of stakeholders –national governments; community members; civil society organizations; the private sector; and researchers – in terms of their stakes in working towards SDG progress. Then we present how networks across these groups (e.g. at national, regional and global levels, or Multiple Stakeholder Partnerships (MSPs), can help achieve progress, with several current examples. Throughout we balance discussion of challenges, strengths and opportunities in both individual stakeholder approaches and MSPs. We also place special emphasis on the role of research in general and developmental science in particular, in the work of MSPs on the Sustainable Development Goals.